Supervised Learning in an Adaptive DNA Strand Displacement Circuit
نویسندگان
چکیده
The development of DNA circuits capable of adaptive behavior is a key goal in DNA computing, as such systems would have potential applications in long-term monitoring and control of biological and chemical systems. In this paper, we present a framework for adaptive DNA circuits using buffered strand displacement gates, and demonstrate that this framework can implement supervised learning of linear functions. This work highlights the potential of buffered strand displacement as a powerful architecture for implementing adaptive molec-
منابع مشابه
Scaling up digital circuit computation with DNA strand displacement cascades.
To construct sophisticated biochemical circuits from scratch, one needs to understand how simple the building blocks can be and how robustly such circuits can scale up. Using a simple DNA reaction mechanism based on a reversible strand displacement process, we experimentally demonstrated several digital logic circuits, culminating in a four-bit square-root circuit that comprises 130 DNA strands...
متن کاملDesign and Characterization of DNA Strand-Displacement Circuits in Serum-Supplemented Cell Medium.
The functional stability and lifetimes of synthetic molecular circuits in biological environments are important for long-term, stable sensors or controllers of cell or tissue behavior. DNA-based molecular circuits, in particular DNA strand-displacement circuits, provide simple and effective biocompatible control mechanisms and sensors, but are vulnerable to digestion by nucleases present in liv...
متن کاملINTEGRATED ADAPTIVE FUZZY CLUSTERING (IAFC) NEURAL NETWORKS USING FUZZY LEARNING RULES
The proposed IAFC neural networks have both stability and plasticity because theyuse a control structure similar to that of the ART-1(Adaptive Resonance Theory) neural network.The unsupervised IAFC neural network is the unsupervised neural network which uses the fuzzyleaky learning rule. This fuzzy leaky learning rule controls the updating amounts by fuzzymembership values. The supervised IAFC ...
متن کاملAptamer-based sensing platform using three-way DNA junction-driven strand displacement and its application in DNA logic circuit.
We proposed a new three-way DNA junction-driven strand displacement mode and fabricated an aptamer-based label-free fluorescent sensing platform on the basis of this mechanism. Assembling the aptamer sequence into the three-way DNA junction makes the platform sensitive to the target of the aptamer. A label-free signal readout method, split G-quadruplex enhanced fluorescence of protoporphyrin IX...
متن کاملTime-Complexity of Multilayered DNA Strand Displacement Circuits
Recently we have shown how molecular logic circuits with many components arranged in multiple layers can be built using DNA strand displacement reactions. The potential applications of this and similar technologies inspire the study of the computation time of multilayered molecular circuits. Using mass action kinetics to model DNA strand displacement-based circuits, we discuss how computation t...
متن کامل